Guillain Barre Syndrome and Matrix Metalloproteinases
نویسندگان
چکیده
Guillain Barre Syndrome (GBS) is an autoimmune polyneuropathy. There is ascending paralysis seen in this and the onset is rapid, many a times preceded by an infection. Hyporeflex is observed and if respiratory component is involved can lead to death. Both sensory and autonomic nerve involvement is seen [1]. Matrix metalloproteinase (MMP’s) are the biggest family of extra cellular matrix degrading enzymes. They are zinc dependent proteases which have a role in general physiology, development and in pathological processes by acting as mediators of inflammation [2]. MMP’s participate in physiological processes like inflammation, immunity, neurite growth, through pro-neurotropic factors and chemokines/cytokines. In the Central Nervous System (CNS), their role in neurogenesis, axonal guidance and learning and memory has been delineated [3]. A central role of MMP’s and cytokines in mediating inflammatory demyelinating diseases of Central Nervous System (CNS) and Peripheral Nervous System (PNS) has been indicated, with GBS being an example of the latter.
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Comparison of Immunoblotting and ELISA for Detection of Anti-Ganglioside Antibodies in Children with Guillain-Barre Syndrome
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